Definition
A mass of fibrous tissue containing hemosiderin-pigmented
macrophages and multinucleated giant cells, replacing and expanding
part of a bone in primary hyperparathyroidism.
Primary hyperparathyroidism, hyperparathyroidism due to neoplasms or
idiopathic hyperplasia of the parathyroid glands. |
Radiographic Appearance
They appear as single or multiple, well defined lesions,
commonly affecting the facial bones, pelvis, ribs and femora. With
treatment. Brown tumours may demonstrate healing with increased
radiodensity.
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Pathology
Para thyroid glands, two small paired endocrine glands, superior and
inferior, usually found embedded in the connective tissue capsule on
the posterior surface of the thyroid gland; they secrete parathyroid
hormone that regulates the metabolism of calcium and phosphorus.
Brown Tumor
Contrary to a name that suggests otherwise, brown tumors are a
nonneoplastic process. On radiographic evaluation their multifocal
involvement may be misconstrued as metastatic disease; however, the
clinical history of renal failure and secondary hyperparathyroidism
(or primary hyperparathyroidism) usually establishes the diagnosis.
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Brown tumors are known to occur only in the setting of
hyperparathyroidism, and they rarely affect the spinal column.
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Treatment:
Treatment of primary hyperparathyroidsm usually involves performing
a total or subtotal parathyroidectomy, and then stabilisation of the
lesion if mechanical damage has occured. |
Image 1
Brown tumour of nasal structures
Image 2 Brown Tumour of the spine MRI
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Useful Link
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