Coronary Thrombosis

 


Definition
Coronary thrombosis, coronary occlusion by thrombus formation, usually the result of atheromatous changes in the arterial wall and usually leading to myocardial infarction.
 
Radiographic Appearance
Generally unseen on plain radiography, visualised on coronary angiography.
 
Pathology
In most cases atherosclerosis does not produce symptoms until an artery is severely narrowed or a sudden obstruction occurs. Then the symptoms will depend on where the disease has developed. In this part of the body pain or cramps may occur during exercise. When this occurs it is because the area of the body that is affected is not receiving enough blood and oxygen. Examples of this would be chest pain during exercise or leg cramps while walking. In most cases these symptoms tend to develope slowly as the artery narrows but if an obstruction occurs such as a blood clot lodged in an artery, the symptoms may appear suddenly.
 
Treatment:
Medication. Medications that lower cholesterol or control high blood pressure may be prescribed. Medication also is available that has been shown to significantly increase pain-free walking distance and total walking distance in people with intermittent claudication. Other medications that help prevent blood clots or the build-up of plaque in the arteries are available, as well.

Angioplasty. In this procedure, an interventional radiologist inserts a very small balloon attached to a thin tube (catheter) into a blood vessel through a small nick in the skin. The catheter is threaded under X-ray guidance to the site of the blocked artery. The balloon is inflated to open the artery. In some cases, a tiny metal cylinder, or stent, is left behind in the artery to keep it open.

Thrombolytic therapy. This treatment is used by an interventional radiologist if the blockage in the artery is caused by a blood clot. Thrombolytic drugs - sometimes called clot-bursting drugs - dissolve the clot and restore blood flow. Usually, the drugs are administered through a catheter directly into the clot. These drugs are frequently combined with another treatment, such as angioplasty.

Bypass grafts. In this procedure, a vein graft from another part of the body or a graft made from artificial material is used to create a detour around the blocked artery. Bypass grafts typically require surgery, but other ways of placing the grafts without major surgery are now being developed.

 

Image 1

Digital Subtraction Angiography Demonstrating an occlusion

 

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